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Procedures used to generate Bmal1 lox/lox / Pax8-rtTA /LC-1 Cre mouse strain (bred on the genetic background of the C57BL/6J mouse from The Jackson Laboratory) were described previously (12)

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For example, while low-dose polyphenols stimulate endogenous antioxidant defenses, high concentrations, such as those found in concentrated supplements, can act as potent pro-oxidants, leading to increased oxidative stress and cellular damage 51