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These cytokines disrupt the production of key ECM proteins, including collagen type II and aggrecan, while promoting the synthesis of matrix metalloproteinases (MMPs), which leads to ECM degradation and further progression of OA [2]

Compared with the osteoarthritis (OA) patient-derived FLSs, the levels of cGAS mRNA and cGAS protein were higher in RA-FLSs

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The first is through oral capsules or tablets of Vitamin B12

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It is tidy, repeatable, and easy to place inside normal schedules