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Results from in vitro and in vivo studies demonstrated that ALA modulates various oxidative stress pathways suggesting its application, alone or in combination with other functional substances, as a useful support in numerous conditions, in which the balance oxidantantioxidant is disrupted, such as neurodegenerative disorders

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Cellular uptake of nanocarriers The incubation of brain endothelial cells with nanocarriers did not decrease the impedance of monolayers reflecting good cell viability (Fig