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Iron not only produces ROS directly, but also participates in the synthesis of iron-containing LOXs that oxidize polyunsaturated fatty acids (PUFAs) to result in lipid peroxides ( Lipid Metabolism in Ferroptosis The accumulation of lipid ROS is the key process in initiating and executing ferroptosis, which is a complex process involving a lot of lipid metabolism productions (Magtanong et al., 2016

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

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Not only type 1 DM but also insulin resistance induced by a high-fat diet in rats increased the levels of ROS in salivary glands, parallel to a reduced salivary flow rate

Soothing gut inflammation and improving vagal tone can help stabilize these autonomic responses