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DISSECTION P938 - ESOC25-2421 CADASIL Argentine Registry (CADASILar): Establishing a Harmonized Clinical Protocol preliminary data Julieta Rosales 1 , Carolina Ardohain 2 , Juan Lopez 3 , Fabio Gonzalez 4 , Julian Alonso 5 , Valentin Selvaggi 6 , Diana Cristalli 7 , Ismael Calandri 2 1 Clinica Sagrada Familia-ENERI, Buenos Aires, Argentina, 2 FLENI, Buenos Aires, Argentina, 3 Sanatorio Los Arcos, Buenos Aires, Argentina, 4 Hospital Italiano de Bs As, Buenos Aires, Argentina, 5 Hospital Posadas, Buenos Aires, Argentina, 6 Hospital Ramos Meja, Buenos Aires, Argentina, 7 Centro Jesi, Buenos Aires, Argentina Background and Aims: CADASIL, a leading monogenic small vessel disease caused by NOTCH3 mutations, manifests with migraines, strokes, and cognitive decline

Therefore, you need to consult a healthcare provider for a personalised treatment plan

The role of the myelin sheath is to protect the nerves from becoming damaged

The Pernicious Anaemia Society notes this is recognised but not fully understood

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Patients should be assessed on disease activity, stability, and treatment intensity, and then categorized roughly as high, moderate, or low risk with respect to Ramadan fasting (Figure 1): High Risk Fasting Not Advised: This group includes patients with severe, active, or unstable disease where fasting is likely to cause harm