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2.3 Neonatal jaundice may reduce risk of PD development 2.3.1 Mechanisms underlying early development of DA neurons During mammalian embryonic development, Ventral Tegmental Area (VTA) DA neurons arise from the midbrain floor plate, where radial glial-like neural progenitors differentiate into three functionally distinct populations (Garritsen et al., 2023

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A study showed that Mthfr deficiency in mice exacerbated the PD-like symptoms in Mthfr +/ mice such as motor function impairments, elevated microglial activity in the substantia nigra, and increased oxidative stress in dorsal striatum suggesting that Mthfr deficiency heightens the vulnerability of substantia nigra and dorsal striatum to paraquat-induced damage [171]

J.FrenchN.ParkK.et al (2021)