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Contraindications to sciatic nerve block may include include local infection and bed sores at the site of insertion, coagulopathy, preexisting central or peripheral nervous systems disorders, and allergy to local anesthesia

Therefore, higher doses of oral vitamin B12 can still be used in these patients to ensure normal levels of B12

UNSW academic van de Ven says that the fact that substances are marketed as natural gives users a false sense of safety