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Ethics statement The animal study was approved by the animal study protocol was approved by the Ethical Committee of Animal Experimentation of the University of Zaragoza (PD10/21NE) for studies involving animals

Therefore, we aim to address the principles of redox biology, exploring the role of redox imbalance in chronic and degenerative diseases, as well as the importance of endogenous and exogenous non-enzymatic antioxidant systems in maintaining cellular homeostasis

Accordingly, the circadian transcriptions factors CLOCK and BMAL1 exert a transcriptional control of Nrf2 expression via E-box elements in the Nrf2 gene promoter, thereby regulating Nrf2 protein accumulation in circadian manner and triggering a rhythmic expression of its antioxidant target genes 91

Jin (2008)

Oxidation of T(SH) 2 results in the formation of an intramolecular disulfide (TS 2 ), which is kinetically favored compared to the intermolecular disulfide formed in GSSG [44]