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10.1016/j.fct.2007.09.085 728

Hyperglycemia can also disrupt the mitochondrial electron transport chain and lead to excess electron binding with O 2 to O 2 (Rehni et al., 2015)

In order to meet this challenge, Proteolysis-Targeting Chimeras (PROTACs) have become a transformative method for targeted protein degradation (TPD) [6,7,8,9]

Together these highlight multiple levels of regulation and ultimately need to be understood in an integrated manner to appreciate the role of NAD + biology in fine-tuning immunoregulation