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Numerous studies support the safety and efficacy of creatine supplementation, with a variety of benefits ranging from muscle hypertrophy to neuroprotective effects

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Chronically elevated cortisol: Promotes visceral fat accumulation specifically, the metabolically dangerous intra-abdominal fat Drives hepatic glucose output, raising fasting blood sugar Suppresses adiponectin, a hormone that improves insulin sensitivity Increases appetite for calorie-dense foods by elevating ghrelin relative to leptin Impairs thyroid hormone conversion from T4 to active T3 This is why metabolic syndrome so frequently co-presents with sleep disorders

2016 PMC4717270 Grimaldi, D

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10.1038/s41467-019-13668-3 123 MartinsG