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As further described below, anti-cancer agents encompass biotherapeutic anti-cancer agents (e.g., interferons, cytokines (e.g., tumor necrosis factor, interferon alpha, interferon gamma, etc.), vaccines, hematopoietic growth factors, monoclonal serum therapies, immunostimulants and/or immunomodulators (e.g., IL-1, 2, 4, 6 and/or 12), immune cell growth factors (e.g., GM-CSF), and antibodies (e.g., trastuzumab (trastuzumab), T-DM1, bevacizumab (bevacizumab), cetuximab (cetuximab), panitumumab (panitumumab), rituximab (rituximab), tositumomab (tositumomab), etc.), as well as chemotherapeutic agents

Zundel MT , Feih JT , Rinka JR , et al

10.1038/376768a0 [DOI] [PubMed] [Google Scholar] Blasi F

Moreover, TFR1 blocking monoclonal antibody, the administration of which hinders iron endocytosis and triggers combined immunodeficiency, was reported to activate altruistic and non-proliferating T cells (61)

Lipman, G

Stavitskaya L Evaluating kratom alkaloids using PHASE