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Adding Cu during oocyte maturation (4-6 g/ml of IVM medium) notably increased both intracellular glutathione content and DNA integrity of cumulus cells, 49 decreased apoptosis, and improved subsequent embryo development up to blastocyst stage

Walsh NP, Oliver SJ

The piRNA pathway allows for a quick and targeted reaction to acute transposable element activation by amplifying piRNAs complementary to active transposon sequences