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Description

In China, APG-115 is the first MDM2 inhibitor used in the clinic

2013;14(10):R115

Their increased specificity often translates to a distinct toxicity profile, although off-tumor, on-target effects are still common

A.WurteleE

Tumor microenvironment (TME) is typically characterized by its hypoxia and acidic pH, where cancer cells can produce large amounts of H 2 O 2 and GSH for their metabolism and resistance to immunological killings