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Additionally, clinically relevant early life events, such as lower respiratory tract infections, can predispose individuals to fixed airflow limitation later in life

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Metformin use and clinical outcomes among patients with diabetes mellitus with or without heart failure or kidney dysfunction: observations from the SAVOR-TIMI 53 trial

40,41 However, most of the prior LAMA studies were conducted in patients with moderate to severe COPD unlike the GOLDEN studies which, as mentioned previously, included a patient population that closely mimicked a real-world COPD population by including very severe patients, those with CV risk, and patients on background LABA

Int J Mol Sci (2023) 24(9):8163