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Within the glutathione system, GSH plays a pivotal role in maintaining ER homeostasis

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4.2.2 Role of CBD in controlling protein expression Recent research has demonstrated that CBD can target the expression of Kelch-like ECH-associated protein 1 (Keap1) and Nrf2 in pulmonary artery smooth muscle cells, potentially boosting its antioxidant benefits in a model of pulmonary arterial hypertension (96)

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Arienti C, Tesei A, Verdecchia GM, Framarini M, Virz S, Grassi A, Scarpi E, Turci L, Silvestrini R, Amadori D, Zoli W