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Even if their primary molecular targets are not strictly mitochondrial, these compounds modulate mitochondriainflammasome crosstalk by attenuating downstream consequences of mitochondrial distress

Located at key interfaces, including the BBB, meninges, and perivascular spaces, mast cells are uniquely positioned to detect environmental stressors and rapidly respond by releasing a potent cocktail of mediators such as histamine, tryptase, cytokines, and prostaglandins

Annually, millions of tons of agro-waste are generated worldwide, with over 90% in low-income nations being incinerated or discarded in open spaces, exacerbating environmental deterioration (137)

The prepared ligands were subsequently subjected to a structure-based virtual screening process with the Glide module of the Schrodinger suite

Therefore, the absence of an association between selenium status and NWCS is unsurprising

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