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Chronic illnesses such as hypertension, diabetes, and obesity can trigger adverse metabolic shifts, resulting in Na + , H + , and Ca 2+ overload, leading to cellular acidosis and damage, and increasing energy consumption in cardiac myocytes, leading to inadequate energy supply and potentially progressing to heart failure

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This facilitates conversion of the -glutamyl bond of GSH into an acyl bond, releasing Cys-Gly and glutamate (11)

BMJ [Internet]

Massage with fingertips for 30 to 60 seconds per section

Active skin infection at the treatment site