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Availability of data and materials The FASTA files used for phylogenetic analyses, the PDB files containing the inferred structures and the Newick tree files are provided in Zenodo ( Positively selected amino acid inferences are publicly available at B + database ( under project BP2018000005

CTSL, a pH-dependent endo-lysosomal protease, cleaves the S-protein and facilitates viral fusion with the host endosomal membrane

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