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As with all GLP-1 agonists, long-term post-marketing surveillance will be essential to characterize the pancreatic safety profile with greater statistical precision, particularly for rare events such as acute pancreatitis (estimated background rate of approximately 35 per 100,000 person-years in the general population) and the theoretical concern about pancreatic cancer

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Accordingly, our results showed that CSF-derived Acly and Acat2, an enzyme downstream of Acly, are both downregulated following targeting CD38 in 5xFAD mice