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For instance, oxidative stress caused by the deposition of -amyloid protein (A) plays an important role in the pathogenesis of AD (Schubert et al., 1995), and the neurotoxicity of cisplatin to neuronal cells has also been confirmed and recognized (Troy et al., 2000)

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Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure

While there is some evidence that some NAD + precursors can improve physical function in older individuals, such an outcome seems unrelated to and independent of changes in skeletal muscle mitochondrial function

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Combined with exercise, this produces a firmer, fitter physique and improved physical performance