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Initially described as a pro-atherogenic molecule due to its proliferative role in VSMC, it was further demonstrated that the effect of IGF-I on VSMC was to compensate for local apoptosis, and that, overall, IGF-I is not pro-atherogenic in native arteries but anti-atherogenic[320], mainly through enhanced nitric oxide production[308]

The molecule has to penetrate the stratum corneum (the skin's outer barrier) to reach the dermis where collagen is actually produced

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Some clinical studies have reported that higher intratumoral butyrate levels correlate with lower inflammatory scores and improved immune cell infiltration in colorectal cancer patients [126]

The involvement of the three main inflammatory bowel disease pathways and the secretion of trypsin proteolytic activity on intestinal epithelial cells