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Reduced energy production: Mitochondrial dysfunction leads to fatigue, cognitive decline and metabolic disorders

For example, the triphenylphosphonium-modified copper complex TPP-CuET accumulates in mitochondria and disrupts the TCA cycle, ATP synthesis, and electron transport, thus amplifying immunogenic cuproptosis

Fecal matter from metformin-treated mice attenuates intestinal ferroptosis induced by IIRI To investigate the role of the gut microbiota in the anti-ferroptosis effect of metformin, we established a dirty cage group by allowing mice to feed on metformin-modulated feces from the MET group

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As delirium duration predicts long-term cognitive decline after critical illness, these findings support a model in which delirium propagates neuronal injury, thereby contributing to post-ICU cognitive impairment