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Sci Rep 7:9217

Low immunogenicity of LNP allows repeated administrations of CRISPRCas9 mRNA into skeletal muscle in mice

H.AbruzziK

Upon activation, Nrf2 translocates to the nucleus, binds specifically to the Antioxidant Response Element (ARE) and induces transcription of downstream genes (Baird and Dinkova-Kostova, 2011) (Figure 2B)