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Titration Slowly increasing the dose over weeks instead of starting at the target dose

Xie J, et al

Caecal ligation and puncture A commonly used preclinical rodent model to study sepsis via ligation and perforation of the caecum, resulting in polymicrobial infection and systemic inflammation

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Upon exposing germ-free mice to elite-survivor dirty cages or FMT via oral administration of feces, specific pathogen-free mice had significantly higher rates of survival than non-FMT controls

doi: 10.1038/nrendo.2013.172