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These sORF produce bioactive peptides, collectively known as mitochondrial-derived peptides (MDP), which have a wide range of physiological functions and can explain how mitochondria communicate within and between cells in a specific disease environment (5)

This energy impairment likely results in a hypometabolic state as the illness progresses (401, 407, 413), called the cell danger response (414416)

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Gene expression analysis indicated elevated CCL21 and CXCL2 levels on day 1, while VEGFA and VEGFC did not appear to drive vascular remodeling

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