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This impairment is related to abnormalities in the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor, which may result from disorganization of the actin stress filaments and abnormalities in the redox status of frataxin-deficient cells [9]

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In addition to mechanical effects, CAFs secrete pro-survival cytokines and chemokines that reinforce platinum resistance

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Because a single ferroptosis pathway is more likely to trigger resistance to ferroptosis, multiple pathways should be coupled to promote ferroptosis in tumor cells at the same time

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