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While numerous studies have identified genetic mutations in nuclear genes, including PRSS1, PRSS2, SPINK1, CFTR, CTRC, CASR, and CLDN2, which are strongly associated with different forms of pancreatitis (153, 154), studies have also explored the potential role of mitochondrial DNA (mtDNA) mutations in the diseases pathogenesis

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LDH activity was detected by automatic biochemical analyzer (Mindray, BS-200) with its commercial bio-kit at 340 nm according to manufacturer's protocol

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