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In addition, the differentially expressed lncRNAs, microRNAs, and mRNAs between the LSF and HSF groups were much more numerous than those with the same changing trends in both the LSF and HSF groups, when compared with the NFD group

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Thapa et al., 2021)

Long R3 IGF-1 has a lower binding affinity for binding proteins such as IGFBP-3, which means it can circulate freely in the bloodstream and exert its anabolic effects on muscle cells without being inhibited by these binding proteins