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Methylation regulation of lpcat3 improves osteoarthritis by regulating acsl4 to inhibit chondrocyte ferroptosis

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AA amino acid AhR aryl hydrocarbon receptor BA bile acid CA cholic acid CDCA chenodeoxycholic acid DCA deoxycholic acid FXR farnesoid X receptor GF germ free GLP glucagon-like peptide GMB gut microbiome GPCR G-protein-coupled receptor HDAC histone deacetylase IBD inflammatory bowel disease IEC intestinal epithelial cell IL interleukin LCA lithocholic acid LPS lipopolysaccharide NLR NOD-like receptor NLRP Node-like receptor protein NOD nucleotide-binding oligomerization domain-containing protein PAMP pathogen-associated molecular pattern PGN peptidoglycan PRR pattern recognition receptor SCFA short chain fatty acid T2D type 2 diabetes TLR Toll-like receptor TMAO trimethyl N-oxide Treg regulatory T cells Trp tryptophan VDR vitamin D receptor Glossary Footnotes References 1

Injection volume of 10 ul for HSA and 2 ul for other proteins were used

Epigenetics 15 (1), 159

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