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Furthermore, it was demonstrated that exogenous pyruvate, functioning as a complementary substrate, impeded the reduction of fumarate under CB-839 treatment conditions

4, e128308, 128308 Knottnerus, S

It is widely accepted that OCD is characterized by neuronal hyperactivity, or at least increased metabolism, in certain key brain areas chiefly the orbitofrontal cortex, the caudate nucleus, and the anterior cingulate cortex (Maia et al., 2008