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In older children with mild disease, a 1 mg daily oral treatment regimen is suggested ( The different recommended doses, formulations and treatment schedules both between and within these countries highlight the important disparity in international clinical practice for the treatment of this heterogenous condition

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In mice lacking functional ZIP4 in intestinal epithelial cells, Paneth cells became Zn deficient, displayed reduced Sox9 and lysozyme expression, and resulted in disorganization of villus and crypt structures (133)

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175 Recent advancements include the development of neuroprotective agents 114,176 with potentially profound implications for patient care