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Description

First, targeting the epigenetic landscape could reprogram terminally exhausted T cells into a more functional state

The oxidation of guanine through a one-electron loss produces 7,8-dihydro-8-oxo-2-guanine (8-oxoGua), while a one-electron gain forms 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua)