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Furthermore, the cellular therapy with KHYG1, CD38KO NK cells or g - NK cells protects the immune activity of NK cells by upregulating the quantity or activity of CD38 low/- NK cells and preventing the HLA-E-mediated immune evasion to maximize the effects of CD38 mAb against MM

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While the trial failed to demonstrate a significant slowing in disease progression with either dose, the findings suggested that a subgroup of patients with early ALS and moderate disease progression could potentially benefit from the higher dose

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PMID 21623471