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But stress, toxins, poor diet and other lifestyle factors that increase its use will speed up depletion

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doi:10.1016/j.ekir.2019.05.001 89 Ostermann M, Summers J, Lei K, et al

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The impact of disease-causing mutations in Parkin and PINK1 on mitophagy are being examined in more physiologically related setting with the aid of induced pluripotent stem cell (iPSC)-derived neurons from PD patients

Clearly, the conclusions of this review should be interpreted as hypothesis-generating rather than definitive, especially for indications with mixed evidence