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Isolated or combined disruption of MeCbl and AdoCbl levels indicates failures in intracellular processing (cblC, cblX), trafficking (cblD), and/or coenzyme biosynthesis and utilization (cblA, cblB, cblG, cblE, mut)

ROS-induced HIF-1 stabilisation leads to the activation of macrophages in the early stages of wound healing, and promotes metabolic reprogramming towards glycolysis 75,76 , as well as increased angiogenesis 76