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11.2.0 software (SAS Institute, Cary, NC, USA)

The participants were randomly assigned to receive metformin 850 mg twice daily or placebo for 3.2 years, and those in the metformin group received metformin for an additional 9 years

Multiple randomized trials have shown that pentoxifylline, alone or in conjunction with compression bandaging, accelerates healing of chronic venous ulcers (Jull 2012

VHMs showed numerous degradative autophagic vacuoles (black arrows) containing melanin or melanosomes (Fig

Therefore, continued rigorous research is needed

More serious side effects, although rare, can include allergic reactions, chest pain, severe dizziness, or numbness in extremities