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23, Rome: Food and Agriculture Organization of the United Nations

Theoretical concerns about chronic NNMT inhibition include effects on the metabolism of other quinolinium and methylpyridinium endogenous metabolites and on the broader cellular methylation landscape

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More importantly, many people have underlying issues that block B12 absorption, regardless of what they eat

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In states of obesity and aging, NNMT is often overexpressed, leading to the excessive methylation and excretion of nicotinamide