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To counter this constant evolution, seasonal vaccines are redesigned annually on predictions of what will be the dominant circulating variants in the upcoming flu season. Predictions must be made significantly ahead of time owing to the time needed to manufacture sufficient doses of vaccine, which can lead to mismatches between vaccine and circulating strains that almost universally lead to limited efficacy

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Check local coverage determinations (LCDs) Review payer-specific guidelines Understand bundling rules with preventive services Always link an appropriate diagnosis code, and if applicable, report the drug separately using its respective J code

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Those seeking dramatic immediate effects should adjust expectations or consider different approaches