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Despite these advances, KRAS inhibitors like sotorasib face resistance mechanisms primarily through the activation of bypass pathways such as autophagy and PI3K-AKT signaling

Additionally, a pilot study on eight female undergraduate students with sleep disorder demonstrated that a 4-week administration of Amyloban 3399 was associated with an improvement in anxiety and sleep quality, measured by the increase in the salivary level of free 3-methoxy-4-hydroxyphenylglycol, a biological index of anxiety disorders [124]

During iron overload, nuclear translocation of the transcription factor EB enhances the autophagic degradation of ferritin and the uptake of lipids, thereby contributing to ferroptosis and aggravating the pathological progression of NASH [205]

Ahmad F, Haque S, Ravinayagam V, Ahmad A, Kamli MR, Barreto GE, Ghulam MA (2020) Developmental lead (Pb)-induced deficits in redox and bioenergetic status of cerebellar synapses are ameliorated by ascorbate supplementation