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While the mechanism is not fully known, this might also couple to the activation of TORC1 by methionine (Sutter et al., 2013)

This occurs through the abnormal overexpression of MMPs, including MMP-2, MMP-9 and MMP-14, which stimulate the development of invasive pseudopodia in tumor cells and aid in the spread of intercellular vesicles (46-49) (Fig

The former encodes amino acids K464-G511, including the critical residues F490 and F508, and therefore removal of exon 11 is predicted to disrupt the interaction of CEP192 with Aurora-A (Fig