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(2) Departamento de Medicina, Universidade Federal da Bahia- UFBA, Salvador, BA, Brasil Diabetology & Metabolic Syndrome 2026: PO240 Introduction: Diabetes mellitus (DM) has a growing global prevalence, posing a significant public health problem

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These numbers had never been observed with a pharmacological agent outside bariatric surgery making tirzepatide a genuine milestone in metabolic medicine

Newer evidence, however, showed that, for major disorders such as AD, PD and FTD, lysosomal components commonly are the primary target of causative and risk gene mutations 84,85 , as discussed below