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Iozzo P, Bucci M, Roivainen A, Nagren K, Jarvisalo MJ, Kiss J, Guiducci L, Fielding B, Naum AG, Borra R, Virtanen K, Savunen T, Salvadori PA, Ferrannini E, Knuuti J, Nuutila P (2010) Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals

Individuals continue taking the medication even when it causes financial, relationship, or legal problems

10.1016/j.biortech.2011.06.055 44 ChenS.LuoJ.HuM.GengP.ZhangY

Inflammopharmacology 26:349360 Shen L, Ji HF (2013) Low uric acid levels in patients with Parkinsons disease: evidence from meta-analysis

In addition to PHGDH, serine hydroxymethyltransferase (SHMT) is also implicated in tumorigenesis

TNF- stimulates the production of IL-1 and IL-6, thereby reinforcing a positive feedback loop that sustains inflammation [47]