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Statins exerted a chemo-protective effect in endometrial cancer ( Sorafenib, a novel oral targeted therapy, can inhibit the serine/threonine kinase activation of RAF-1 and B-Raf, as well as the tyrosine kinase activation of vGFR-2, VEGF-3, PDGF-, KIT, and FLT-3 receptors ( ( in vitro (Sun et al., 2013), while it showed a limited effect on both uterine carcinoma and uterine carcinosarcoma in a multi-center phase II clinical study (Nimeiri et al., 2010)

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