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The most affected brain regions containing a high amount of neuromelanin and a high concentration of copper are the locus coeruleus and substantia nigra (Davies et al., 2013[106])

Classical apoptosis remains the dominant mode of follicular loss: double-strand breaks trigger ATM/ATR-p53 signalling, up-regulating BAX/BAK and prompting mitochondrial outer-membrane permeabilisation with cytochrome-c release [78,79,80,81]