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Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]

M.PapadimitriouA.SilvaK

Vacuum erection devices offer another mechanical approach, helping maintain penile length and potentially reducing curvature progression

doi: 10.1038/s41392-020-00454-7

To address this issue, a hydrogel-based bioadhesive dry powder has been developed for pulmonary inhalation, with particles smaller than 5 m in diameter, allowing for deeper lung deposition 30,31