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2 Other crucial areas of uncertainty in clinical practice are related to the intensity and duration of DOAC therapy in patients with provoked VTE with enduring risk factors, 24 the efficacy and safety of DOACs for thromboprophylaxis in patients with mechanical valves, and the utility of DOACs for treatment of patients with left ventricular thrombus or heparin-induced thrombocytopenia

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doi:10.1056/NEJMoa2206038

Pharmacological Reports , 2018 Neurological and NO Pathway Regulation: Emerging data suggests that BPC-157 may modulate nitric oxide (NO) and dopamine systems, which could explain its potential for nerve regeneration and mood regulationthough lower doses may be more appropriate for systemic neurological use

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