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The previously reported inhibitor-bound structures of Ec GUS reveal that the selective GUS inhibitors make contacts with both the Loop 1 of the primary monomer as well as the Loop 1 of the adjacent monomer in its functional C-term-mediated tetrameric state (Fig

If NCOA4 383522 were acting as a dimer in this assay, we expected binding similar to NCOA4 383522 lacking motif mutations, as each singly mutated NCOA4 383522 would still have one motif available to bind to one subunit of the GST-GATE16 dimer

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Moreover, we will discuss the therapeutic potential of regulating lipid peroxidation and chondrocyte ferroptosis for OA

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Role of PQQ in energy metabolism PQQ has garnered significant attention due to its potential role in energy metabolism, and associated health benefits including anti-aging impacts