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The ChIP-seq data for H3K27ac in HCT116 cells was downloaded ( GSM2571028)

4.1.2 Impact of pyruvate kinase and lactate on macrophage phenotype Pyruvate kinase is a key enzyme in the glycolysis pathway: it catalyzes the dephosphorylation of phosphoenolpyruvate into pyruvate and is responsible for the production of ATP during glycolysis

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Such similarities include the presence of a vascular and systemic pro-inflammatory and pro-oxidant state, 109115 reduced NO synthesis and endothelial dysfunction, 116120 arterial stiffening 121124 and an increased risk of arterial hypertension

Glutathione is a powerful antioxidant that is naturally produced in our bodies but can also be obtained from external sources