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Figure 4 5 Challenges and future directions 5.1 Microbiota therapy challenges: from mechanisms to solutions Despite promising progress, personalized gut microbiota therapies encounter significant challenges

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In the liver, DCs not only participate in inducing immune tolerance and regulating T cell responses (Tong et al., 2023), but also modulate intrahepatic homeostasis and the fibrotic process ( In healthy livers, DCs are relatively sparse and exhibit limited capabilities in antigen phagocytosis and T cell stimulation

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Microglial polarization was subsequently analyzed by flow cytometry