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The observed frequency mismatch therefore does not contradict the role of peripheral damage in initiating central hyperactivity

For example, in a myocardial reperfusion injury model, curcumin inhibits ferroptosis, autophagy, and apoptosis by upregulating HES1, effectively reducing tissue damage (172)

3- Clinical uses and practicality: HGH has been proven for GH deficiency, short-term gains in lean mass/fat loss, but needs strict indication because of safety/monitoring needs

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Jones 3 , Bolin Niu 4 , George Therapondos 5 , Mae Thamer 6 , Onkar Kshirsagar 6 , Yi Zhang 6 , Paulo Pinheiro 7 , Ronnie Fass 8 , Mandana Khalili 9 and Amit G